The reference site for Quinapril

Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.

WHAT IS QUINAPRIL?

Quinapril is used for treating high blood pressure and heart failure and for preventing kidney failure due to hypertension and diabetes.

Quinapril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors lower blood pressure by inhibiting the formation of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. This increases the flow of blood and oxygen to the heart so that it can pump blood more efficiently. The enlargement of the arteries elsewhere in the body also makes it easier for the heart to pump blood. This is particularly beneficial when there is heart failure.

In the kidneys, this increases blood flow and reduces the filtration pressure in the kidneys.

 

Brand Name(s): Accupril
CAS nº: 85441-61-8
(kwin’ a pril)

 

Product Info

The sections below will provide you with more specific information and guidelines related to quinapril and its correct use. Please read them carefully.

FDA Information

The U.S. Food and Drug Administration approved Accupril®, also known as quinapril hydrochloride, in November 1991 for the treatment of high blood pressure (hypertension) and heart failure.

Why is this medication prescribed?

Quinapril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors are used for treating high blood pressure and heart failure and for preventing kidney failure due to hypertension and diabetes.

ACE inhibitors such as quinapril lower blood pressure by inhibiting the formation of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. This increases the flow of blood and oxygen to the heart so that it can pump blood more efficiently. The enlargement of the arteries elsewhere in the body also makes it easier for the heart to pump blood. This is particularly beneficial when there is heart failure. In the kidneys, for example, this increases blood flow and reduces the filtration pressure in the kidneys.

Other drugs in the class of ACE are enalapril (Vasotec®), ramipril (Altace®), captopril (Capoten®), fosinopril (Monopril®), benazepril (Lotensin®), lisinopril (Zestril, Prinivil®), moexipril (Univasc®) and trandolapril (Mavik®).

Other uses for this medicine

This medication may also be used to treat congestive heart failure.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Quinapril comes as a tablet to take by mouth. The recommended dose for treating hypertension is 10-80 mg a day as a single dose or in two doses. The dose for heart failure is 20-40 mg a day in two divided doses.

It is usually taken once or twice a day.

To help you remember to take quinapril, take it around the same time every day.

Take quinapril exactly as directed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of quinapril and gradually increase your dose, not more than once every one or two weeks.

NOTE: Quinapril controls high blood pressure and heart failure but does not cure them.

Continue to take quinapril even if you feel well. Do not stop taking quinapril without talking to your doctor.

What special precautions should I follow?

BEFORE TAKING QUINAPRIL:

Tell your doctor if you have ever had an allergic reaction that involved swelling of your lips, face, tongue, or throat or difficulty breathing.

Inform your doctor if you have kidney disease; liver disease; are on a salt-restricted diet or have high levels of potassium in your blood; are taking salt substitutes, potassium supplements (e.g., K-Dur, Klor-Con), or potassium-sparing diuretics such as amiloride (Midamor), triamterene (Dyrenium, Dyazide, Maxzide), or spironolactone (Aldactone); or have diabetes.

You may not be able to take quinapril, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Quinapril is in the FDA pregnancy category D. This means that quinapril is known to be harmful to an unborn baby. When used during the second and third trimesters of pregnancy, quinapril can cause injury and even death to the developing baby. Do not take quinapril if you are pregnant or could become pregnant during treatment.

Quinapril passes into breast milk, and its effects on a nursing infant are not known. Therefore, do not take quinapril without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Some common side effects from quinapril include:

dizziness
swelling
headache
dry cough

Tell your doctor if any of these symptoms are severe or do not go away:

dizziness
excessive tiredness
cough
upset stomach
vomiting

If you experience any of the following symptoms, call your doctor immediately:

swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
hoarseness
difficulty breathing or swallowing
yellowing of the skin or eyes
fever, sore throat, chills, and other signs of infection
chest pain
lightheadedness
fainting

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

dizziness
weakness
fainting

Product Images

PICTURES OF QUINAPRIL PILLS

Below you will find images and specific information on the principal types of quinapril that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: QUINAPRIL
Strength(s): 5 MG
Imprint: G 022 5
Manufacturer: GREENSTONE LTD.

Name: QUINAPRIL
Strength(s): 5 MG
Imprint: 18
Manufacturer: TEVA USA

Name: QUINAPRIL
Strength(s): 5 MG
Imprint: PD 527 5
Manufacturer: PFIZER US PHARM.

Name: QUINAPRIL
Strength(s): 10 MG
Imprint: RX 549
Manufacturer: TEVA USA

Name: QUINAPRIL
Strength(s): 10 MG
Imprint: A 242
Manufacturer: PAR PHARM.

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